Myelofibrosis (MF) is a rare bone marrow disease. This disease usually disrupts the production of blood cells in the body. MF develops slowly and doesn’t always display any noticeable symptoms, so diagnosing this condition can be difficult.
After proper diagnosis, if the doctor suspects that a person is suffering from MF, the doctor is likely to conduct a further series of tests including a physical exam, blood test, and imaging test.
People who are suffering from Polycythemia vera (PV), they are at a higher risk of developing MF.
Symptoms of Myelofibrosis:
Due to the increased levels of disruption of normal blood cell production, these symptoms are visible-
Tiredness and weakness
Shortness of breathing
Pain or fullness below the ribs on the left side, due to an enlarged spleen
Excessive sweating during sleep
Causes of Myelofibrosis:
Myelofibrosis (MF) generally occurs when the bone marrow thickens and turns into a scar tissue. Still, there is no known cause of MF, but some people are at more risk of developing MF.
MF sometimes can result from the progression of two blood conditions, namely Polycythemia vera (PV) and Essential Thrombocythemia (ET).
Experts think that a genetic mutation in blood stem cells might cause the condition of MF. However, researchers are not sure what causes these cells to get a mutation. Mutations in the JAK2, MPL, and CALR genes have been associated with the development of MF.
Who is at risk for MF?
Some factors are known to increase the chance of developing MF, including:
Genetics: People with mutations or changes in certain genes can increase the risk of developing this condition.
Age: MF can affect anyone of any age, but usually it’s diagnosed in people in their 50s and 60s.
Other blood cell diseases: Suffering from PV or ET can lead a person to develop MF.
Exposure to Radiation: Exposure to high levels of radiation for a long time can increase the risk to develop MF.
Exposure to certain chemicals: Being in contact with certain industrial chemicals such as toluene or benzene also can increase the chances of developing MF.
Since the condition is incurable, the affected person has to carry it for the rest of their life in many cases. Still, there are some treatments available for easing the symptoms. Talk to your doctor or schedule an appointment with a Haematologist from https://tiyo.in/